Southport ended Macclesfield’s four-game winning run after both sides were reduced to 10 men early on.
With 19 minutes gone, Andy Bishop and Neill Byrne were given straight red cards after an incident at a corner.
Louis Almond’s fine run and shot put the hosts ahead, but Danny Whitaker levelled from the spot after Matty Challoner fouled Chris Holroyd.
Almond then scored a penalty after Mike Phenix was impeded, before assisting Josh Thompson to slot home the third.
- 25 Crocombe, 02 Challoner, 12 Blakeman, 06 Foster, 05 Thompson, 16 Rutherford (Joyce – 46′ ),17 Almond (Nolan – 83′ ), 08 Wright (Ryan – 62′ ), 10 Bishop Dismissed,11 Jones, 22 Phenix
- 04 Nolan, 09 Stockton, 14 Joyce, 19 Viscosi, 24 Ryan
- 13 Jalal, 12 Cowan, 19 Fitzpatrick, 09 Holroyd, 15 Diagne, 04 Byrne Dismissed, 06 Turnbull Booked, 11 Rowe (Pilkington – 23′ ), 18 Whitehead (Churchman – 82′ Booked ), 23 Whitaker, 10 Sampson
- 01 Branagan, 02 Halls, 05 Pilkington, 14 Dennis, 24 Churchman
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